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The following
information is provided for general information purposes
ONLY. |
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| What is Altrenogest? |
| Altrenogest is an orally administered synthetic
progestational agent. It has a chemical name of 17
-hydroxyestra-4,9,11-trien-3-one. Altrenogest may
also be known as allylbalpha-Allyl-17 trenbolone . |
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| Storage of Altrenogest |
| Altrenogest oral solution should be stored at room
temperature. |
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| How does Altrenogest work? |
| Altrenogest is primarily produced endogenously by
the corpus luteum. It transforms proliferative
endometrium to secretory endometrium, enhances
myometrium hypertrophy and inhibits spontaneous
uterine contraction. Altrenogest has a
dose-dependent inhibitory effect on the secretion of
pituitary gonadotropins and also has some degree of
estrogenic, anabolic and androgenic activity. |
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| What is Altrenogest used for? |
| Altrenogest is indicated to suppress estrus in mares
to allow a more predictable occurrence of estrus
following withdrawal of the drug. It is used
clinically to assist mares to establish normal
cycles during the transitional period from anoestrus
to the normal breeding season often in conjunction
with an artificial photoperiod. It is more effective
in assisting in pregnancy attainment later in the
transition period. One group of authors suggest
selecting mares with considerable follicular
activity (mares with one or more follicles 20 mm or
greater in size) for treatment during the
transitional phase. Mares that have been in estrus
for 10 days or more and have active ovaries are also
considered to be excellent candidates for progestin
treatment. |
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| Altrenogest is effective in normally cycling mares
for minimizing the necessity for estrus detection,
for the synchronization of estrus and permitting
scheduled breeding. Estrus will ensue 2-5 days after
treatment is completed and most mares ovulate
between 8-15 days after withdrawal. Altrenogest is
also effective in suppressing estrus expression in
show mares or mares to be raced. Although the drug
is labeled as contraindicated during pregnancy, it
has been demonstrated to maintain pregnancy in
oophorectomized mares and may be of benefit in mares
who abort due to sub-therapeutic progestin levels. |
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| Interaction of Altrenogest |
| Rifampin may decrease altrenogest activity if
administered concomitantly. This is presumably due
to microsomal enzyme induction with resultant
increase in altrenogest metabolism. The clinical
significance of this potential interaction is
unknown. |
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| Pharmacokinetics of Altrenogest |
| The pharmacokinetic parameters of altrenogest were
not found. Other progestin agents are rapidly
metabolized by the liver. |
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| Precautions of Altrenogest |
| Pregnancy is a contraindication to the use of
altrenogest, however it has been used clinically to
maintain pregnancy in certain mares. Altrenogest
should also not be used in horses intended for food
purposes. |
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| Adverse effects of Altrenogest |
| Adverse effects of altrenogest appear to be minimal
when used at labeled dosages. One study found
negligible changes in hematologic and most
“standard” laboratory tests after administering
altrenogest to 4 groups of horses over 86 days.
Occasionally, slight changes in Ca++, K+, alkaline
phosphatase and AST were noted in the treatment
group, but values were only slightly elevated and
only noted sporadically. No pattern or definite
changes could be attributed to altrenogest. No
outward adverse effects were noted in the treatment
group during the trial. |
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| Use of progestational agents in mare’s with chronic
uterine infections should be avoided as the
infection process may be enhanced. |
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| Altrenogest can be absorbed after skin contact and
absorption can be enhanced if the drug is covered by
occlusive materials (e.g.,
under latex gloves,
etc.). If exposed to the skin, wash off immediately
with soap and water. If the eyes are exposed, flush
with water for 15 minutes and get medical attention.
If the product is swallowed, do not induce vomiting
and contact a physician or poison control center. |
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| Overdosage of Altrenogest |
| The LD50 of altrenogest in is 175-177 mg/kg in rats.
No information was located regarding the effects of
an accidental acute overdose in horses. |
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| Disclaimer: |
| Information on this page is provided for general
information purposes. You should not make a clinical
treatment decision based on information contained in
this page without consulting other references
including the package insert of the drug, textbooks
and where relevant, expert opinion. We cannot be
held responsible for any errors you make in
administering drugs mentioned on this page, nor for
use of any erroneous information contained on this
page. |
