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Amorolfine
API |
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Haorui supplies high quality Amorolfine API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Amorolfine API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is
Amorolfine HCI? |
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Amorolfine is a morpholine derivative that is used topically
as an antifungal agent. Amorolfine has a broad spectrum of
activity, including dermatophytes filamentous and
dematiaceous fungi, yeasts and dimorphic fungi. Its activity
is fungicidal for most species. Amorolfine can penetrate
into the nail rapidly and achieve concentrations higher than
the MICs obtained for most of the fungi causing
onychomycosis. Amorolfine’s clearance is slow following
topical application. Amorolfine has been ineffective when
administered orally to animals with systemic fungal
infections. This lack of activity may be due to protein
binding and/or rapid metabolism of the drug. |
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How does
Amorolfine HCI work? |
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Amorolfine blocks delta 14 reduction and delta 7-8
isomerisation, which causes depletion of ergosterol and
accumulation of ignosterol in fungal cytoplasmic membrane.
Fungal cell wall becomes thicker and chitin deposits are
formed inside and outside the cell wall. |
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What is
Amorolfine HCI used for? |
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Amorolfine is used to treat tinea
(fungal) infections of the finger and toe nails. Tinea
infections are also sometimes known as ringworm, which may
be caught from another person, from an animal, from soil,
from the floors of showers, or from household objects, such
as chairs or carpet.
While amorolfine achieves clinical treatment in around 40 to
55% of patients with mild tinea infections, those with
severe tinea infections involving the nail bed require
systemic treatment. |
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Amorolfine is also effective also to various
superficial dermatomycosis. However, cream and vaginal
tablet formulations of amorolfine are not available anymore.
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How many
doses of Amorolfine are usually taken? |
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Amorolfine 5% nail lacquer is applied once or twice a week
for up to 6 months in tinea infections |
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In various superficial dermatomycoses, amorolfine cream has
previously been used once daily on the infected area for up
to 6 weeks |
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Precautions of using Amorolfine: |
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Before using any of this preparation make
sure your doctor or pharmacist knows:
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if you are pregnant, trying for a baby or
breast-feeding |
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if you have ever had an allergic reaction
to this or any other medicine |
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if you are using any other preparations,
including those available to buy without a prescription,
herbal and complementary medicines |
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Amorolfine HCI side effects
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Amorolfine
occasionally causes skin irritation such as redness,
itching, or a burning sensation. This should soon disappear.
If it doesn't or if it becomes severe, stop using Amorolfine
and ask your doctor or pharmacist for advice. |
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Storage of Amorolfine |
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Keep out of reach of children.
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Store in a cool, dry place, away from
direct light and heat. |
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Never keep out of date or unwanted
medicines. Discard them safely out of the reach of
children or take them to your local pharmacist who will
dispose of unwanted medicines for you. |
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Usage of Amorolfine |
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Use Amorolfine exactly as directed by your
doctor. |
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Always read the manufacturer's information
leaflet, if possible, before beginning treatment. This
will contain instructions for using the product.
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Amorolfine is usually applied once or
twice a week, after filing and cleaning the nails, as
directed. |
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Allow Amorolfine to dry after applying.
This usually takes around three minutes.
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Disclaimer: |
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Information on this page is provided for general
information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page.
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