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Aztreonam
API |
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Haorui supplies high quality Aztreonam API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Aztreonam API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Aztreonam?
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Aztreonam
is an antibiotic that is used to treat infections caused
by bacteria. It works by killing bacteria or preventing
their growth. Aztreonam is used to treat bacterial
infections in many different parts of the body. It is
sometimes given with other antibiotics. This medicine
will not work for colds, flu, or other viral infections.
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How does Aztreonam
work?
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Aztreonam
is the only clinically available member of a unique
class of beta-lactam antibiotics called 'monobactams'.
As such, it is structurally related to the other beta-lactams:
penicillins, cephalosporins, and carbapenems (e.g.
imipenem, meropenem).
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Aztreonam's
spectrum of activity is specific to Gram-negative
organisms, including Haemophilus influenzae and
Pseudomonas aeruginosa. Recent reports from the United
states suggest over 88% of strains of P. aeruginosa from
cystic fibrosis (CF) patients are susceptible to
aztreonam (Shawar et al 1999). Activity against
Burkholderia cepacia is variable but activity against
Stenotrophomonas maltophilia and Alcaligenes
xylosoxidans is generally poor. It has no anti-Gram
positive activity and therefore has no role in the
treatment of Staphylococcus aureus (including MRSA) or
Streptococcus pneumoniae.
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What is Aztreonam
used for?
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Aztreonam
is an antibiotic that is related to the penicillin/cephalosporin
family of antibiotics. It kills a specific range of
bacteria. It works by interfering with their ability to
form cell walls, and therefore the bacteria break up and
die.
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Aztreonam
is given by injection or infusion and is therefore
generally used for more serious infections. If the
bacterium causing an infection is not known, it should
be used in conjunction with another antibiotic so that a
wider range of organisms is targeted. It may be less
likely to cause an allergic reaction in people who have
had allergic reactions to penicillin in the past.
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Aztreonam side effects
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Check
with your doctor immediately if any of the following side effects of Aztreonam occur:
(Less
common or rare)Black,
tarry stools; blood in urine or stools;
burning or itching of vagina; chest pain;
chills; confusion; convulsions
(seizures); cough; dark urine;
diarrhea ; difficulty in breathing;
discharge from vagina; discomfort, inflammation,
or swelling at the injection site;
dizziness; eye pain; fever; flu-like
symptoms; general feeling of illness;
headache; hives; light gray-colored
stools; loss of appetite; numbness of
tongue; pinpoint red spots on skin; seeing
double; skin rash, redness, or itching; sore
throat; unusual bleeding or bruising;
unusual tiredness or weakness; yellow skin or eyes. Abdominal
or stomach cramps; altered sense of taste;
bad breath; breast tenderness; burning or
prickling feeling of skin; flushing;
increased sweating; mouth ulcers; muscular
aches; nasal congestion; nausea or
vomiting; ringing, buzzing, or noise in ear;
small, nonraised, round, purplish or red spots on
skin; sneezing; trouble in
sleeping |
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Aztreonam Special Conditions To Observe
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Allergies:
Tell
your doctor if you have ever had any unusual or allergic
reaction to aztreonam. Also tell your health care
professional if you are allergic to any other
substances, such as foods, preservatives, or dyes.
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Breast-feeding:
Aztreonam
passes into the breast milk in small amounts. However,
this medicine is not absorbed when taken by mouth, and
problems have not been seen in nursing babies.
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Older
adults: Aztreonam
has been tested in a limited number of patients 65 years
of age or older and has not been shown to cause
different side effects or problems in older people than
it does in younger adults.
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Children:
Studies
have been done in children and have shown that aztreonam
is effective in treating certain bacterial infections
and that side effects in children are similar to those
experienced by adults. Elevations of liver enzymes and
reductions in white blood cell counts were seen in
children who were given high doses of this medicine or
who had more serious infections.
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Pregnancy:
Studies
have not been done in humans. However, aztreonam has not
been shown to cause birth defects or other problems in
studies in rabbits and rats given up to 15 times the
highest human daily dose.
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Disclaimer:
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Information
on this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held responsible
for any errors you make in administering drugs mentioned
on this page, nor for use of any erroneous information
contained on this page.
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