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Bicalutamide
API |
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Haorui supplies high quality Bicalutamide API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Bicalutamide API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Bicalutamide? |
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Bicalutamide is a man-made
drug that is used in the treatment of prostate cancer. It is
a type of hormonal therapy. Hormonal therapies interfere
with the production or action of particular hormones in the
body. Hormones are substances produced naturally in the
body. They act as chemical messengers and help to control
the activity of cells and organs. |
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How does Bicalutamide work?
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Most prostate cancers need
supplies of the male hormone testosterone to grow. This is
produced by the testes and adrenal glands. On the surface of
the prostate cancer cells are proteins called receptors.
Bicalutamide has a structure similar to the male sex hormone
testosterone. It works by blocking and preventing
testosterone from attaching (binding) to the receptors on
the surface of the prostate cancer cells. Without
testosterone, the cancer cells either grow more slowly,or
stop growing altogether. The cancer may shrink in size. |
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Bicalutamide may be used on
its own to treat prostate cancer that has begun to spread
into the tissues outside the prostate gland (locally
advanced). It is no longer recommended for men with prostate
cancer that is contained within the prostate gland (early
prostate cancer). In prostate cancer that has spread to
other parts of the body (advanced or metastatic),
bicalutamide may be given in combination with injections of
another type of hormonal therapy drug such as goserelin,
buserelin, triptorelin or leuprorelin. These drugs block the
production of a hormone produced by the pituitary gland (leuteinising
hormone), which stimulates the production of testosterone |
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Precautions of Bicalutamide
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Before taking
bicalutamide
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tell your doctor and pharmacist if you are allergic to
bicalutamide or any other drugs. |
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tell your doctor and pharmacist what prescription and
nonprescription medications you are taking, especially
anticoagulants ('blood thinners') such as warfarin (Coumadin),
aspirin, aspirin-substitute products, and vitamins.
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tell your doctor if you have or have ever had liver
disease. |
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you
should know that this drug may stop sperm production.
However, you should not assume that you cannot get someone
else pregnant. You should not plan to have children while
receiving chemotherapy or for a while after treatments.
(Talk to your doctor for further details.) Use a reliable
method of birth control to prevent pregnancy. Bicalutamide
may harm the fetus. |
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you
should know that this drug should not be used in women,
especially women who are or could become pregnant.
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do not have any
vaccinations (e.g., measles or flu shots) without talking
to your doctor. |
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Bicalutamide side effects |
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Many people have very few
side effects with bicalutamide but others may experience
more. The side effects described as the following will not
affect everyone and may be different if you are takinging
more than one drug. We have outlined the most common side
effects. However, we have not included those which are very
rare and therefore extremely unlikely to affect you.
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Some people may have some of
the following side effects.
Breast tenderness or
fullness
Some men may notice slight breast swelling and tenderness
known as gynaecomastia. Your doctor can prescribe medicines
to reduce any discomfort. |
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Hot flushes
These are usually mild and may wear off after a period of
time. There are a number of ways to help reduce hot flushes
and sweats. It can be useful to avoid or cut down on tea,
coffee, nicotine and alcohol. Let your doctor know if hot
flushes are causing you any problems as recent research
suggests that progesterone or some anti-depressants may be
helpful in controlling this side effect. |
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Itching and dryness
of the skin
This is usually mild. Let your doctor know if it is a
problem for you. Sometimes creams or medications can reduce
this effect. |
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Nausea (feeling
sick), vomiting and mild diarrhoea
These effects are usually mild and easily controlled. Nausea
can sometimes be relieved by taking the tablet with food.
Let your doctor know if you have any of these side effects
as medicines can be prescribed to help. |
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Lowering of libido,
and loss of ability to have an erection
If these effects occur, sexual function will return to
normal after stopping the drug. Your doctor or nurse can
discuss this with you. |
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Drowsiness and
weakness
Occasionally bicalutamide may cause feelings of weakness and
drowsiness. |
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Blood in the urine
A rare side effect of bicalutamide is blood in the urine (haematuria).
Let your doctor know if you have this |
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Storage of Bicalutamide |
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Keep
bicalutamide in the container it came in, tightly closed,
and out of the reach of children. Store it at room
temperature and away from excess heat and moisture (not in
the bathroom). Throw away any medication that is outdated or
no longer needed. Talk to your pharmacist about the proper
disposal of your medication. |
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Disclaimer:
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Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
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