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Doxazosin
mesylate
API
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Haorui supplies Doxazosin mesylate
API (Active Pharmaceutical Ingredients) to
pharmaceutical industry. Our bulk Doxazosin
mesylate actives is produced by GMP facility.
Welcome
to contact us for product detail.
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The following information is
provided for general information purposes ONLY.
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What is Doxazosin Mesylate?
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Doxazosin
Mesylate is used for the control of elevated blood
pressure (hypertension) and for benign prostatic
hyperplasia (noncancerous enlargement of the prostate
gland). Doxazosin Mesylate is an inhibitor of the alpha
1 adrenergic nervous system. It is in a class of drugs
referred to as alpha-blockers that includes alfusosin (Uroxatral),
terazosin (Hytrin), tamsulosin (Flomax), and prazosin (Minipress).
Elevated blood pressure (hypertension) is lowered as the
action of these nerves, which promote constriction of
blood vessels, is blocked. Doxazosin Mesylate was also
found to relax the muscles around the prostate gland,
which is also under the influence of the alpha-adrenergic
portion nervous system. This can makes urination easier
for men affected by enlarged prostate glands.
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How does Doxazosin Mesylate
work?
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Blocks
the alpha-1 (postjunctional) adrenergic receptors
resulting in a decrease in systemic vascular resistance
and a corresponding decrease in BP. Peak plasma
levels: 2-3 hr. Peak effect: 2-6 hr.
Significantly bound (98%) to plasma proteins.
Metabolized in the liver to active and inactive
metabolites, which are excreted through the feces and
urine. T1/2:
22 hr.
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What is Doxazosin Mesylate
used for?
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Doxazosin Mesylate is an inhibitor of the alpha 1 adrenergic
nervous system, which promotes the constriction of blood
vessels. Hypertension is lowered as the action of these
nerves is blocked. Doxazosin Mesylate was also found to
relax the muscles around the prostate gland, which is
also under the influence of the alpha-adrenergic portion
nervous system. This can makes urination easier for men
affected by enlarged prostate glands.
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Doxazosin
Mesylate mode of action
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Doxazosin
Mesylate should be taken at doses specifically directed
by your physician. This medication can be taken with or
without food. Doxazosin Mesylate should be taken the
same time each day to maintain proper blood levels. Do
not take Doxazosin Mesylate within two hours of taking
an antacid. If stopped you must taper the dose. Store in
a dry place at 30 degrees C (86 F).
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Doxazosin
Mesylate side effects
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An uncommon but dangerous side effect of Doxazosin Mesylate is a
drop in the white blood cells, which normally help to
fight infection. Liver damage is uncommon. Dizziness and
fainting can occur if the blood pressure is lowered too
fast. Swelling of the ankles and fatigue may occur. Most
persons should have periodic blood studies while taking
Doxazosin Mesylate. This medication will rarely cause
nausea, headaches, anxiety, insomnia, drowsiness, nasal
congestion and sexual dysfunction. Consult your
pharmacist and physician for additional drug
interactions. This medication should be taken while
pregnant only if strongly indicated.
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Dizziness (most frequent), syncope, vertigo, lightheadedness, edema,
palpitation, arrhythmia, postural hypotension,
tachycardia, peripheral ischemia. CNS: Fatigue,
headache, paresthesia, kinetic disorders, ataxia,
somnolence, nervousness, depression, insomnia. Musculoskeletal:
Arthralgia, arthritis, muscle weakness, muscle cramps,
myalgia, hypertonia. GU: Polyuria, sexual
dysfunction, urinary incontinence, urinary frequency. GI:
Nausea, diarrhea, dry mouth, constipation, dyspepsia,
flatulence, abdominal pain, vomiting. Respiratory:
Fatigue or malaise, rhinitis, epistaxis, dyspnea. Miscellaneous:
Rash, pruritus, flushing, abnormal vision,
conjunctivitis, eye pain, tinnitus, chest pain,
asthenia, facial edema, generalized pain, slight weight
gain.
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Doxazosin
Mesylate Special Conditions To Observe
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Use with caution during lactation, in impaired hepatic function, or in
those taking drugs known to influence hepatic
metabolism. Safety and effectiveness have not been
demonstrated in children. Due to the possibility of
severe hypotension, do not use the 2-, 4-, and 8-mg
tablets for initial therapy.
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Disclaimer:
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Information on
this page is provided for general information purposes.
You should not make a clinical treatment decision based
on information contained in this page without consulting
other references including the package insert of the
drug, textbooks and where relevant, expert opinion. We
cannot be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use
of any erroneous information contained on this page.
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