Estradiol API

Haorui supplies high quality Estradiol API produced by our GMP facility that has been successfully inspected by the FDA. We offer competitive prices and support our products with reliable technical and regulatory services.  Estradiol API is available from R&D to commercial quantities. Please contact us for more details.

  The following information is provided for general information purposes ONLY.

What is Estradiol?

Estradiol is an oral hormone, used to reduce the symptoms of menopause: hot flashes, feelings of warmth in the face, neck and chest or dry, itchy external genitals and vaginal irritation.

How does Estradiol work?

One of the fascinating twists to mammalian sexual differentiation is that estradiol is one of the two active metabolites oftestosterone in males (the other being dihydrotestosterone). Estradiol cannot be transferred readily from the circulation intothe brain. Since fetuses of both sexes are exposed to similarly high levels of maternal estradiol, it can play little role inprenatal sexual differentiation. However, testosterone enters the central nervous system more freely and significant amounts arearomatized to estradiol within the brain of most male mammals, including humans. There is now much evidence that theprogramming of adult male sexual behavior in "lower mammals," (such as mounting behavior rather than lordosis ), is largely dependent on estradilo produced in the central nervous system during prenatal life andearly infancy from testosterone. We do not yet know whether this process plays a minimal or significant part in human sexualbehaviors.

Estradiol  interaction:

Tell your doctor of all prescription and nonprescription drugs you may use, especially of: hydantoins (e.g., phenytoin), barbiturates (e.g., phenobarbital), corticosteroids (e.g., prednisone). This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

What is Estradiol used for?

This medication is a hormone and is given to women who no longer produce the proper amount. It is used to reduce menopause symptoms (e.g., hot flashes), for brittle bones (osteoporosis), and treats certain cancers in both men and women.

How do I use Estradiol?

May be taken with food or immediately after a meal to prevent stomach upset. Take this medication as prescribed. Follow the dosing schedule carefully. Be sure to ask your doctor if you have any questions.

Estradiol precautions:

Before having surgery, tell the doctor that you take this drug. Depending on strength, this drug may cause a patchy, darkening of the skin on the face (melasma). Higher strengths are more likely to cause melasma. Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing. Cigarette smoking can increase the chance of blood-clots while taking this medication (especially in women past the age of 35). This drug should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This drug may be excreted into breast milk and its use is not recommended while breast-feeding. Consult your doctor before breast-feeding.

Estradiol side effects

May cause dizziness, lightheadedness, headache, stomach upset, bloating, or nausea. These effects should disappear as your body adjusts to the medication. Notify your doctor if you experience: severe depression, calf pain, sudden severe headache, chest pain, shortness of breath, lumps in the breast, weakness or tingling in the arms or legs, yellowing of the eyes or skin, changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or complete stoppage of bleeding), stomach pain, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.

What should I do If I overdose Estradiol?

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea/vomiting or stoppage of periods.

What should I do if I miss a dose?

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Estradiol storage

Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.

Estradiol warning

This drug has been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause. This risk appears to depend on the length of time this drug is used and the amount of estrogen per dose. If you use this drug for an extended period, you should be evaluated at least every 6 months. If you experience abnormal vaginal bleeding, notify your doctor promptly. This medication is not effective in preventing or treating a tendency toward miscarriages (natural habitual abortion) nor the threat of miscarriage. This drug must not be used during pregnancy because its use may result in birth defects or cancer later in the child's life. If you become pregnant or think you may be pregnant, consult your doctor immediately to discuss the risk to the fetus.

Disclaimer:

Information on this page is provided for general information purposes. You should not make a clinical treatment decision based on information contained in this page without consulting other references including the package insert of the drug, textbooks and where relevant, expert opinion. We cannot be held responsible for any errors you make in administering drugs mentioned on this page, nor for use of any erroneous information contained on this page.