|
Estrdiol API |
|
|
|
Haorui supplies Estrdiol
API (Active
Pharmaceutical Ingredients) to pharmaceutical
industry. Our bulk Estrdiol actives is produced by
FDA approved cGMP
facility.
Welcome
to contact us for product detail. |
|
|
|
The following information is provided for
general information purposes ONLY. |
|
|
|
What is Estrdiol? |
|
Estrdiol is an
oral hormone, used to reduce the symptoms of menopause: hot
flashes, feelings of warmth in the face, neck and chest or
dry, itchy external genitals and vaginal irritation.
|
|
|
|
How does Estrdiol work? |
|
One of the
fascinating twists to mammalian sexual differentiation is
that estradiol is one of the two active metabolites
oftestosterone in males (the other being dihydrotestosterone).
Estrdiol cannot be transferred readily from the circulation
intothe brain. Since fetuses of both sexes are exposed to
similarly high levels of maternal estrdiol, it can play
little role inprenatal sexual differentiation. However,
testosterone enters the central nervous system more freely
and significant amounts arearomatized to estrdiol within
the brain of most male mammals, including humans.
There is now much evidence that theprogramming of adult male
sexual behavior in "lower mammals," (such as mounting
behavior rather than lordosis ), is largely dependent on
estrdilo produced in the central nervous system during
prenatal life andearly infancy from testosterone. We do not
yet know whether this process plays a minimal or significant
part in human sexualbehaviors. |
|
|
|
Estrdiol interaction: |
|
Tell your doctor of
all prescription and nonprescription drugs you may use,
especially of: hydantoins (e.g., phenytoin), barbiturates
(e.g., phenobarbital), corticosteroids (e.g., prednisone).
This product can affect the results of certain lab tests.
Make sure laboratory personnel and your doctors know you use
this drug. Do not start or stop any medicine without doctor
or pharmacist approval. |
|
|
|
What is Estrdiol used for?
|
|
This medication is
a hormone and is given to women who no longer produce the
proper amount. It is used to reduce menopause symptoms
(e.g., hot flashes), for brittle bones (osteoporosis), and
treats certain cancers in both men and women. |
|
|
|
How do I use Estrdiol?
|
|
May be taken with
food or immediately after a meal to prevent stomach upset.
Take this medication as prescribed. Follow the dosing
schedule carefully. Be sure to ask your doctor if you have
any questions. |
| |
|
Estrdiol effects: |
 |
Breast development
and maintenance |
|
Adding fat to
breasts, hips, thighs during puberty |
|
Improving bone
strength and density |
|
Accelerating bone
maturation and bringing epiphyses to closure, completing
growth |
|
Growth of the
uterus |
|
Development of the
endometrial lining to a thickness necessary to support
pregnancy and menstruation |
|
Promoting and
maintaining vaginal mucosal thickness and secretions
|
|
Serving as the
primary feedback to the brain of sex hormone levels in
both males and females. |
|
| |
|
Estrdiol precautions: |
|
Before you take
this medication, tell your doctor your entire medical
history, including:
|
family medical history (especially breast lumps and cancer |
|
high blood pressure |
|
diabetes |
|
asthma |
|
epilepsy (seizures) |
|
migraine headaches |
|
liver disease, |
|
heart disease, |
|
kidney disease |
|
depression |
|
high blood pressure during pregnancy |
|
jaundice (yellowing skin/eyes) during pregnancy |
|
excessive weight gain and fluid retention (bloating) |
|
blood clots or stroke, cholesterol or lipid gallbladder
problems |
|
|
|
|
Before having
surgery, tell the doctor that you take this drug. Depending
on strength, this drug may cause a patchy, darkening of the
skin on the face (melasma). Higher strengths are more likely
to cause melasma. Sunlight may intensify this darkening and
you may need to avoid prolonged sun exposure and sunlamps.
Consult your doctor regarding use of sunscreens and
protective clothing. Cigarette smoking can increase the
chance of blood-clots while taking this medication
(especially in women past the age of 35). This drug should
not be used during pregnancy. If you become pregnant or
think you may be pregnant, inform your doctor immediately.
This drug may be excreted into breast milk and its use is
not recommended while breast-feeding. Consult your doctor
before breast-feeding. |
|
|
|
Estrdiol side effects |
|
May cause
dizziness, lightheadedness, headache, stomach upset,
bloating, or nausea. These effects should disappear as your
body adjusts to the medication. Notify your doctor if you
experience: severe depression, calf pain, sudden severe
headache, chest pain, shortness of breath, lumps in the
breast, weakness or tingling in the arms or legs, yellowing
of the eyes or skin, changes in vaginal bleeding (spotting,
breakthrough bleeding, prolonged or complete stoppage of
bleeding), stomach pain, skin rash. If you notice other
effects not listed above, contact your doctor or pharmacist. |
|
|
|
What should I do If I overdose Estrdiol? |
|
If overdose is
suspected, contact your local poison control center or
emergency room immediately. Symptoms of overdose may include
nausea/vomiting or stoppage of periods. |
|
|
|
What should I do if I miss a dose? |
|
If you miss a
dose, take as soon as remembered; do not take if it is
almost time for the next dose, instead, skip the missed dose
and resume your usual dosing schedule. Do not "double-up"
the dose to catch up. |
|
|
|
Estrdiol
storage |
|
Store at room
temperature between 59 and 86 degrees F (between 15 and 30
degrees C) away from moisture and sunlight. Do not store in
the bathroom. |
|
|
|
Estrdiol warning |
|
This drug has been
reported to increase the chance of womb (endometrial) cancer
in women who have been through menopause. This risk appears
to depend on the length of time this drug is used and the
amount of estrogen per dose. If you use this drug for an
extended period, you should be evaluated at least every 6
months. If you experience abnormal vaginal bleeding, notify
your doctor promptly. This medication is not effective in
preventing or treating a tendency toward miscarriages
(natural habitual abortion) nor the threat of miscarriage.
This drug must not be used during pregnancy because its use
may result in birth defects or cancer later in the child's
life. If you become pregnant or think you may be pregnant,
consult your doctor immediately to discuss the risk to the
fetus. |
|
|
|
Disclaimer:
|
|
Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
