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Fludarabine Phosphate
API |
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Haorui supplies high quality Fludarabine Phosphate API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Fludarabine Phosphate API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
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What is Fludarabine
Phosphate?
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Fludarabine
phosphate belongs to the general group of
chemotherapy drugs known as antimetabolites. It is
used to treat chronic lymphocytic leukemia that no
longer responds to at least 1 standard treatment
with an alkylating agent.
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How does Fludarabine
Phosphate work?
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Fludarabine
phosphate prevents cells from making DNA and RNA by
interfering with the synthesis of nucleic acids,
thus stopping the growth of cancer cells.
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The history of Fludarabine
Phosphate
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FDA
Approval:This
drug is approved for cancer treatment.
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Fludarabine
Phosphate mode of action
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Fludarabine
phosphate is usually given as an injection in a vein
over 30 minutes once a day for 5 days. A pill form
is being studied. The dose depends on your size, how
well your kidneys are working, and your blood
counts.
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Fludarabine
Phosphate pharmacokinetics
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Fludarabine Phosphate
contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-ß-D-arabinofuranosyladenine
(ara-A) that is relatively resistant to deamination by adenosine deaminase. Each vial of sterile lyophilized solid cake contains
50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The pH range for the final product is 7.2-8.2. Reconstitution with 2
mL of Sterile Water for Injection USP results in a solution containing 25 mg/mL of
fludarabine phosphate
intended for intravenous
administration.
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The
chemical name for fludarabine phosphate is 9H-Purin-6-amine,
2-fluoro-9-(5-0-phosphono-ß-D-arabino-furanosyl)
(2-fluoro-ara-AMP).The molecular formula of fludarabine phosphate is C10H13FN5O7P (MW 365.2).
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Fludarabine
Phosphate side effects
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Decreased
white blood cell count with increased risk of
infection
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Decreased
platelet count with increased risk of bleeding
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Tiredness
(fatigue)
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Nausea
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Fludarabine
Phosphate Special Conditions To Observe
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While you are being treated with fludarabine, and after
you stop treatment, do not have any immunizations
(vaccinations) without your doctor’s okay. Try to
avoid contact with people who have recently taken
the oral polio vaccine. Fludarabine can lower your
blood counts (white blood cells, red blood cells,
platelets). Your doctor will check your blood counts
before and after each treatment, to see how it
affects your blood counts. Fludarabine can decrease
your white blood cell count, especially 13 days
after the drug is given. This can increase your risk
of getting an infection. Report fever of 100.5°F or
higher, or signs of infection such as pain in
passing your urine, coughing, and bringing up
sputum. Fludarabine can decrease your platelet
count. This can increase your risk of bleeding. DO
NOT take any aspirin or aspirin–containing
medicines. Report unusual bruising, or bleeding such
as nosebleeds, bleeding gums when you brush your
teeth, or black, tarry stools.
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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