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Ibutilide fumarate
API
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Haorui supplies Ibutilide fumarate API (Active
Pharmaceutical Ingredients) to pharmaceutical
industry. Our bulk Ibutilide fumarate actives is
produced by GMP facilities.
Welcome
to contact
us
for product detail.
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Supply
Ibutilide fumarate
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The following
information is provided for general information purposes
ONLY.
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What is Ibutilide?
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Ibutilide
is an antiarrhythmic drug that was recently marketed for
the rapid conversion of atrial fibrillation and atrial
flutter. After
intravenous administration, Ibutilide is moderately
effective in acheaving prompt conversion to sinus rhythm
with greater efficacy in patients who have atrial
flutter. Ibutilide
is given by vein to convert atrial fibrillation and
flutter of recent onset.
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How does Ibutilide
work?
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Ibutilide
regulates the flow of potassium and sodium in to heart
cells. Since the flow of these ions provides the
basis for electrical signals in the heart, regulation of
this flow can prevent irregular heartbeats.
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The major
Drug Interactions of
Ibutilide
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Many drugs can interact
with ibutilide causing excessive prolongation of the QT
interval. It is essential, therefore, that any
medicines that you are taking are reviewed by your
physician prior to the administration of ibutilide.
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What is Ibutilide
used for?
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Ibutilide
has been classified as a class III antiarrhythmic drug,
although its mechanism is incompletely understood at
present. Ibutilide is used intravenously to convert atrial flutter
or fibrillation to normal rhythm.
The drug is only available in an intravenous
form. When given as an intravenous dose, it has been shown to be
more effective than a nonactive infusion in converting
fibrillation and is also more effective than intravenous
procainamide. The studies with ibutilide to date have looked at atrial
flutter or fibrillation of recent onset, that is less
than six weeks in duration.
Ibutilide is the most effective agent currently
known for intravenous conversion of atrial flutter or
fibrillation. It
is more effective for flutter than fibrillation and the
duration of the arrhythmia appears to be important in
gauging the likelihood that the drug will be effective
or not.
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Ibutilide studies
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Ibutilide can prolong the QT interval on the electrocardiogram
and provoke torsades de pointes (see quinidine,
dofetilide, sotalol, and others).
As with the case with other antiarrhythmic drugs
that can provoke torsades, this risk appears to be
higher in females, in patients with heart disease
(especially a prior history of congestive heart
failure), where there are electrolyte abnormalities, and
where the heart rate is particularly slow.
The risk of torsades with ibutilide appears to be
in the range of about 2% or higher in most of the
published studies.
Ibutilide must be administered, therefore, in a
very carefully-monitored environment where any excessive
prolongation of the QT-interval or a development of new
ventricular arrhythmia can be recognized promptly and be
treated. A
treatment involves stopping ibutilide and, in some
cases, administering intravenous magnesium or other
antiarrhythmic drugs.
If a long-lasting bout of torsades occurs with
loss of consciousness, immediate electrical
defibrillation to restore normal heart rhythm must be
performed. Patients
who are treated with intravenous ibutilide, therefore,
are monitored at the time of the infusion and for about
four hours afterwards by which time the effects of the
drug should have dissipated.
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Vancomycin side effects
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Apart
from the risk of causing torsades, ibutilide is
generally well-tolerated.
It has an interesting effect in that it may
reduce the amount of energy needed for electrical
cardioversion and, therefore, has been used in some
centers where standard electrical cardioversion fails or
is a pretreatment before electrical cardioversion.
In some patients, electrical cardioversion may
allow conversion back to normal rhythm but the patient
immediately goes back into atrial fibrillation.
In these situations, an infusion of ibutilide may
be used to try to stabilize the heart rhythm after
cardioversion. The
usual dose of ibutilide given is 1 mg followed by a
second milligram infusion if the first one is not
effective.
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Disclaimer:
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Information
on this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held responsible
for any errors you make in administering drugs mentioned
on this page, nor for use of any erroneous information
contained on this page.
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