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Linezolid
API |
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Haorui supplies high quality Linezolid API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Linezolid API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Linezolid? |
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Linezolid (li-NE-zoh-lid ) belongs to the
family of medicines called antibiotics. Antibiotics are
medicines used in the treatment of infections caused by
bacteria. They work by killing bacteria or preventing
their growth. Linezolid will not work for colds, flu, or
other virus infections. |
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Linezolid is used to treat infections of
the blood, lungs, and skin. It may also be used for
other conditions as determined by your doctor. It is
given by injection or orally. It is used mainly for
serious infection for which other medicines may not
work. |
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How does Linezolid work? |
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Linezolid prevents
bacteria from making proteins. This causes the bacteria
to die. Linezolid has a different way of attacking
bacteria, so they cannot develop a resistance to it.
Linezolid is used to treat gram–positive organisms,
especially those that are resistant to other antibiotics
such as vancomycin. |
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How do I use Linezolid properly? |
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The liquid
form of linezolid should be gently mixed by
turning the bottle upside down 3 to 5 times before
each dose. Do not shake this product. |
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Do not use after the
expiration date on the label. The medicine may not
work properly after that date. If you have any
questions about this, check with your pharmacist.
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To help clear up your infection
completely, keep taking this medicine for the full
time of treatment, even if you begin to feel better
after a few days. Also, it works best when there is a
constant amount in the blood. To help keep the amount
constant, linezolid must be given on a regular schedule. |
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Precautions of Linezolid mode of
action |
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Linezolid can
lower the number of white blood cells in your blood
temporarily, increasing the chance of getting an
infection. It can also lower the number of platelets,
which are necessary for proper blood clotting. If this
occurs, there are certain precautions your doctor may
ask you to take, especially when your blood count is
low, to reduce the risk of infection or bleeding:
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If you can,
avoid people with infections. Check with your
doctor immediately if you think you are getting an
infection or if you get a fever or chills.
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Check with
your doctor immediately
if you notice any unusual bleeding or bruising.
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Do not touch
your eyes or the inside of your nose unless you have
just washed your hands and have not touched anything
else in the meantime. |
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Be careful not
to cut yourself when you are using sharp objects such
as a safety razor or fingernail or toenail cutters.
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Avoid contact
sports or other situations where bruising or injury
could occur. |
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When taken
with certain foods or drinks, linezolid can cause an
increase in blood pressure. To avoid this, do not eat
large amounts of foods or drink beverages that have a
high tyramine content (most common in foods that are
aged, fermented, pickled, or smoked to increase their
flavor, such as aged cheeses; air-dried, fermented, or
smoked fish, meat, or poultry; sauerkraut; soy sauce;
red wine; or tap beer. If a list of these foods and
beverages is not given to you, ask your health care
professional to provide one. |
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Linezolid
pharmacokinetics |
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Linezolid is highly absorbed when administered
orally, with a bioavailability of approximately 100
percent.15 This allows conversion from
intravenous to oral therapy as soon as the patient is
clinically stable; thus, it provides an advantage over
comparative therapy that can be delivered only
parenterally (i.e., vancomycin or quinupristin/dalfopristin
[Synercid]). Linezolid is metabolized via hepatic
oxidation without any cytochrome P-450 pathways.
Elimination occurs through nonrenal, renal, and fecal
mechanisms accounting for 65, 30, and 5 percent,
respectively. The half-life is approximately five hours.15
Generally, the dosing interval for an antibiotic is
three times the half-life--the dosing interval for
linezolid is every 12 hours. Presently, no dosage
adjustment is recommended for patients with renal
insufficiency; however, linezolid is removed by
hemodialysis and should be administered following
dialysis. |
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Linezolid adverse effects
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Adverse effects reported in clinical trials in
more than 2 percent of patients include the following:
rash, headache, diarrhea, nausea, vomiting, insomnia,
constipation, and fever.15 The incidence was
similar to the comparator groups: ceftriaxone,
clarithromycin (Biaxin), dicloxacillin (Pathocil),
oxacillin (Bactocill), and vancomycin.
Thrombocytopenia, defined as a decrease in
platelet count below 75 percent of normal or baseline,
was reported in 2.4 percent of patients receiving
linezolid versus 1.5 percent in those in the comparator
group.14 This effect may be associated with
the higher dose or treatment duration exceeding two
weeks.
In addition, the FDA has recently reported
cases of myelosuppression (anemia, leukopenia, and
pancytopenia) warranting the monitoring of hematologic
parameters and has issued a warning that
myelosuppression is considered a potential adverse
effect. The current recommendation is to monitor
complete blood count status weekly, especially in
patients receiving therapy longer than two weeks'
duration, those with preexisting myelosuppression, those
receiving drugs that produce bone marrow suppression,
and those with a chronic infection who have received
other antibiotic therapy recently or concurrently. If
myelosuppression occurs, then discontinuation of therapy
should be considered. |
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Linezolid Special Conditions To
Observe |
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Pregnancy—Linezolid has not been
studied in pregnant women. Before taking this medicine,
make sure your doctor knows if you are pregnant of if
you may become pregnant. |
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Breast-feeding—
It is not known whether linezolid passes into breast
milk. Although most medicines pass into breast milk in
small amounts, many of them may be used safely while
breast-feeding. Mothers who are taking this medicine and
who wish to breast-feed should discuss this with their
doctor. |
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Children—Studies
on this medicine have been done only in adult patients,
and there is no specific information comparing use of
linezolid in children with use in other age groups. |
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Older adults—This
medicine
has been tested and has not been shown to cause
different side effects or problems in older people than
it does in younger adults. |
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Allergies—Tell
your doctor if you have ever had any unusual or allergic
reaction to linezolid. Also tell your health care
professional if you are allergic to any other
substances, such as foods, preservatives, or dyes. |
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Disclaimer:
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Information on this page is provided
for general information purposes. You should not make a
clinical treatment decision based on information
contained in this page without consulting other
references including the package insert of the drug,
textbooks and where relevant, expert opinion. We cannot
be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use
of any erroneous information contained on this page.
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