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Olanzapine
API |
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Haorui supplies high quality Olanzapine API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Olanzapine API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Olanzapine? |
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Zyprexa is an antipsychotic in the
thienobenzodiazepine class used to treat emotional and
mood disorders. Zyprexa has been approved to treat
Schizophrenia and acute mania in Bipolar patients. |
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Olanzapine interaction |
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May enhance the effects of alcohol,
centrally-acting drugs, antihypertensive agents; may
antagonize the effects of levodopa and dopamine
agonists. Decreased levels of olanzapine with
carbamazepine, omeprazole. Inhibitors of olanzapine's
metabolism: fluvoxamine, ciprofloxacin, ketoconazole.
Concomitant smoking may increase olanzapine's
metabolism. |
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Olanzapine Pharmacology |
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The mechanism of action of olanzapine, as with
other antipsychotic drugs, is unknown. However, it has
been proposed that this drug's antipsychotic activity is
mediated through a combination of dopamine and serotonin
type 2 antagonism. |
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Olanzapine is well absorbed after oral
administration reaching peak plasma concentrations
within 5 to 8 hours. |
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How should I use Olanzapine properly?
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Olanzapine comes as a
tablet and an orally disintegrating tablet to take by
mouth. It usually is taken once a day. Follow the
directions on your prescription label carefully, and ask
your doctor or pharmacist to explain any part you do not
understand. Take olanzapine exactly as directed. Do not
take more or less of it or take it more often than
prescribed by your doctor. |
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To
take the orally disintegrating tablet, use dry hands to
peel back the foil packaging. Immediately take out the
tablet and place it in your mouth. The tablet will
quickly dissolve and can be swallowed with saliva. No
water is needed to swallow disintegrating tablets. |
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Olanzapine helps treat schizophrenia but does not cure
it. Continue to take olanzapine even if you feel well.
Do not stop taking olanzapine without talking to your
doctor, especially if you have taken large doses for a
long time. Your doctor probably will want to decrease
your dose gradually. This drug must be taken regularly
for a few weeks before its full effect is felt. |
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What should I do if I forget a dose of
Olanzapine? |
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Take
the missed dose as soon as you remember it. However, if
it is almost time for the next dose, skip the missed
dose and continue your regular dosing schedule. Do not
take a double dose to make up for a missed one. |
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Precautions of taking Olanzapine
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Before taking olanzapine,
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tell your
doctor and pharmacist if you are allergic to
olanzapine or any other drugs. |
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tell your
doctor and pharmacist what prescription and
nonprescription medications you are taking, especially
carbamazepine (Tegretol), heart medications,
omeprazole (Prilosec), rifampin (Rifadin), sleeping
pills, tranquilizers, and vitamins.
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tell your
doctor if you have or have ever had heart disease or a
heart attack, seizures, breast cancer, liver or
prostate disease, a bowel obstruction, glaucoma, or if
you or anyone in your family has or has ever had
diabetes. |
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tell your
doctor if you are pregnant, plan to become pregnant,
or are breast-feeding. If you become pregnant while
taking olanzapine, call your doctor.
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you should know
that this drug may make you drowsy. Do not drive a car
or operate machinery until you know how this drug
affects you. |
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remember that
alcohol can add to the drowsiness caused by this drug.
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tell your
doctor if you use tobacco products. Cigarette smoking
may decrease the effectiveness of this drug.
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you should know
that you may have increases in your blood sugar
(hyperglycemia) while you are taking this medication,
even if you do not already have diabetes. If you have
schizophrenia (a mental illness that causes disturbed
or unusual thinking, loss of interest in life, and
strong or inappropriate emotions), you are more likely
to develop diabetes than people who do not have
schizophrenia, and taking olanzapine or similar
medications may increase this risk. Tell your doctor
immediately if you have any of the following symptoms
while you are taking olanzapine: extreme thirst,
frequent urination, extreme hunger, blurred vision, or
weakness.It is very important to call your doctor as
soon as you have any of these symptoms, because high
blood sugar can cause more serious symptoms, such as
dry mouth, upset stomach and vomiting, shortness of
breath, breath that smells fruity, or decreased
consciousness,and may become life-threatening if it is
not treated at an early stage. |
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you should know
that this drug may cause a condition called
neuroleptic malignant syndrome (NMS). If you have
fever, very stiff muscles, change in mental function,
sweating, or irregular heartbeat, call your doctor
immediately. |
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be aware that
olanzapine may cause a condition called tardive
dyskinesia. If you have any uncontrollable jerking
movements, call your doctor immediately.
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Olanzapine side effects
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Side effects that should be reported to
your doctor immediately: Difficulty swallowing; stiff
arms or legs; trembling and shaking of hands and
fingers. |
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Less common:
Chest pain; inability to move eyes; lip smacking or
puckering; muscle spasms of face, neck, and back; rapid
or worm-like movements of tongue; twitching movements;
uncontrolled chewing movements; uncontrolled movements
of arms or legs. |
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Rare:
Confusion; mental or physical sluggishness; swelling of
face; trouble in breathing |
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Olanzapine storage |
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Keep
this medication in the container it came in, tightly
closed, and out of reach of children. Store it at room
temperature and away from moisture and heat (not in the
bathroom). Throw away any medication that is outdated or
no longer needed. Talk to your pharmacist about the
proper disposal of your medication. |
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Disclaimer:
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Information on this page is provided
for general information purposes. You should not make a
clinical treatment decision based on information
contained in this page without consulting other
references including the package insert of the drug,
textbooks and where relevant, expert opinion. We cannot
be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use
of any erroneous information contained on this page.
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