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Palonosetron
HCl
API |
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Haorui supplies high quality Palonosetron HCl API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Palonosetron HCl API is available from R&D to
commercial quantities. Please contact us for more details. |
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Dolasetron
Granisetron
base Granisetron
HCl
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Palonosetron
Ramosetron
Tropisetron |
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The following
information is provided for general information purposes
ONLY. |
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What is
Palonosetron? |
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Palonosetron blocks the
actions of chemicals in the body that may cause nausea and
vomiting. Palonosetron is used to prevent nausea and
vomiting associated with cancer chemotherapy. Palonosetron
may also be used for purposes other than those listed in
this medication guide. |
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How does Palonosetron work?
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Palonosetron is a selective serotonin subtype
3 (5-HT3) receptor antagonist with a strong binding
affinity. 5-HT3 receptors are located on the nerve terminals
of the vagus in the periphery and centrally in the
chemoreceptor trigger zone of the area postrema. Cancer
chemotherapy is associated with nausea and vomiting when
serotonin is released from the enterochromaffin cells of the
small intestine activates 5-HT3 receptors located on vagal
afferents and activates the vomiting reflex. Palonosetron
may also block ion channels involved in ventricular
polarization may prolong action potential duration. The
effect of palonosetron on blood pressure, heart rate, and
ECG parameters including QTc were comparable to ondansetron
and dolasetron in clinical trials. |
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Before Using Palonosetron |
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Do not
take palonosetron without first talking to your doctor if
you:
-have
an allergy or sensitivity to other similar medicines such as dolasetron, granisetron, or ondansetron
-have
low levels of potassium in the blood
-have
low levels of magnesium in the blood
-are
taking a diuretic
-have a
history of congenital QT syndrome
-are
taking a medicine to treat an irregular heartbeat.
Palonosetron may affect the heart, especially if you have
any of the conditions or are taking any of the medicines
listed above.
Palonosetron is in the FDA pregnancy category B. This means
that it is not expected to be harmful to an unborn baby. Do
not take palonosetron without first talking to your doctor
if you are pregnant or could become pregnant during
treatment.
It is
not known whether palonosetron passes into breast milk. Do
not take palonosetron without first talking to your doctor
if you are breast-feeding a baby.
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Palonosetron Drug Interactions |
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Do not take palonosetron without first
talking to your doctor if you are taking any of the
following medicines:
-a diuretic such as furosemide,
bumetanide, torsemide, chlorothiazide, hydrochlorothiazide,
chlorthalidone, indapamide, metolazone, amiloride,
spironolactone, triamterene, and others
-a medicine to treat irregular
heartbeats such as amiodarone, bepridil, disopyramide,
sotalol, and others.
You may not be able to take palonosetron, or
you may require a dosage adjustment or special monitoring
during treatment if you are taking any of the medicines
listed above.
Drugs other than those listed here may also
interact with palonosetron. Talk to your doctor and
pharmacist before taking any other prescription or
over-the-counter medicines, including vitamins, minerals,
and herbal products, during treatment with palonosetron. |
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Palonosetron side effects |
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If you
experience any of the following uncommon but serious side
effects, stop taking palonosetron and seek emergency medical
attention or contact your doctor immediately:
-an allergic reaction (difficulty breathing;
closing of the throat; swelling of the lips, tongue, or
face; or hives)
-irregular heartbeats.
Other, less serious side effects may be more
likely to occur. Continue to take palonosetron and talk to
your doctor if you experience
-headache;
-fatigue or dizziness;
-constipation; or
-diarrhea.
Side effects other than
those listed here may also occur. Talk to your doctor about
any side effect that seems unusual or that is especially
bothersome. |
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What should I do, if I miss a dose? |
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Palonosetron is intended to be used before
administration of chemotherapy. Use of palonosetron during
or following chemotherapy may not be effective. Contact your
healthcare provider if a dose of palonosetron is missed.
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If I overdose, what should I do? |
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Seek
emergency medical attention if an overdose is suspected. Symptoms
of a palonosetron overdose are not well known but might
include seizures, difficulty breathing, pale or blue colored
skin, and collapse.
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Storage of
Palonosetron |
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Palonosetron should
be Stored in a tightly sealed container away from heat,
moisture, and direct light. |
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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