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Rabeprazole
sodium API
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Haorui supplies Rabeprazole sodium
API (Active Pharmaceutical Ingredients) to
pharmaceutical industry. Our bulk Rabeprazole
sodium actives is produced by GMP facility.
Welcome to contact us for
product detail.
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The following information is
provided for general information purposes ONLY.
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What is Rabeprazole?
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Rabeprazole sodium, a
substituted benzimidazole that inhibits gastric acid
secretion.
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How does Rabeprazole work?
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Rabeprazole
is available for oral administration
as delayed-release, enteric-coated tablets containing 20 mg of
rabeprazole sodium. Inactive ingredients are
carnauba wax, crospovidone, diacetylated
monoglycerides, ethylcellulose, hydroxypropyl
cellulose, hypromellose phthalate, magnesium stearate, mannitol, sodium
hydroxide, sodium
stearyl fumarate, talc, titanium dioxide, and yellow ferric oxide as a
coloring agent.
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The history of Rabeprazole
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Rabeprazole
is in a class of drugs called proton pump inhibitors
(PPI), which block the production of acid, by the
stomach. Other drugs in the same class include
lansoprazole lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium). Proton pump inhibitors are used for
the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison
Syndrome that are caused by stomach acid.
Rabeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the
stomach that makes acid. By blocking the enzyme, the
production of acid is decreased, and this allows the
stomach and esophagus to heal.
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Rabeprazole
pharmacokinetics
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Rabeprazole sodium
is known chemically as 2-[[[4-(3-methoxypropoxy)
-3-methyl-2-pyridinyl]-methyl] sulfinyl] -1H–benzimidazole
sodium
salt. It has an empirical
formula of C18H20N3NaO3S
and a molecular weight
of 381.43. Rabeprazole sodium
is a white to slightly
yellowish-white solid. It is very soluble
in water and methanol,
freely soluble in ethanol, chloroform
and ethyl acetate and insoluble in ether and n-hexane. The stability of rabeprazole sodium is a function of pH; it is rapidly degraded in
acid media, and is more stable under alkaline conditions. The structural formula is:
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Rabeprazole side effects
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Rabeprazole
like other PPIs is well tolerated. The most common
side effects are diarrhea, nausea, vomiting, constipation, rash and headaches. Dizziness, nervousness, abnormal heartbeat, muscle pain,
weakness, leg cramps and water retention rarely
occur.
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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