Flumazenil

CAS: 78755-81-4
BP/EP/USP
USDMF No. 17971, USFDA  Approved, CEP: R1-CEP2008-121-Rev01, UK GMP, Stability Studies In Zone IVB
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Technical Data

 

M. Wt 303.29
Formula C15H14FN3O3
CAS Number 78755-81-4
PubChem ID 3373
InChI Key OFBIFZUFASYYRE-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1
Documents CEP, USFDA Approved, USDMF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

 

Description

 

Flumazenil is an imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner.

 

Synonyms

 

Flumazenil, Flumazenilo, Flumazenilum, Flumazepil, Flumazenilo, Romazicon, Anexate, Mazicon, Lanexat, ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

 

Disclaimer

 

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1)

 

Flumazenil